Prof. Dr. Habil. Anisoara Cimpean 

Main scientific domains: Cell cultures, Biomaterials and biocompatibility, Tissue engineering, Stem cells and regenerative medicine, Clinical biochemistry, Cell biology

Habilitation thesis: Developing strategies for in vitro biocompatibility assessment of novel biomaterials  Fisier de tip .pdf ! Habilitation Abstract_Cimpean

Books, Monographies and Courses

1. Cimpean A, Ion R, Ciofrangeanu C, Mitran V, Galateanu B, Iordachescu D, Practical guide for in vitro evaluation of dental implant biocompatibility, 2008, Editura Ars Docendi, ISBN: 978-973-558-364-4 (in romanian language).

2. Gavrila M., Cimpean A., Method of isolation and culture of human mesenchymal stem cells, 2007, Editura Curtea Veche, ISBN 978-973-9467-92-6 (in romanian language).

3. Cimpean A, 2006, Animal Cell Cultures, Editura Ars Docendi, ISBN-10 973-558-274-0; ISBN-13 978-973-558-274-6 (in romanian language).

4. Iordachescu D., Cimpean A., Stan C., 2004, Extracellular matrix remodeling. Applications in tissue engineering, Editura Pro-Transilvania, ISBN 973-715-024-4 (in romanian language).

Book chapters

1. Cimpean, A., Ion, R., Gordin D.-M., Neacsu, P., Mitran, V., Gloriant, T., 2013, Biomaterials as modulators of macrophage inflammatory response, Biomaterials (vol. 11) in: N.K. Navani, S. Sinha (Eds.), J.N. Govil (Executive Ed.), Nanotechnology series, Studium Press LLC (USA), p. 139-176, ISBN: 1-62699-000-X.

2. Dimonie D, Petrache M, Doncea S, Gabor R, Vasile E, Cimpean A, Fierascu RC, Cristian N, Dinescu S, Trandafir I, Anton L, Fierascu I, Galateanu B. 2013. New approaches to develop 3D layer shaped scaffolds for soft tissue engineering, in: Advanced biocompatible structures for prospective bioengineering: Concepts and strategies, The Publishing House of the Romanian Academy, p. 74-124, ISBN: 978-973-27-2317-3.

Papers published in ISI indexed journals (selective)

Neacsu P, Staras AI, Voicu SI, Ionascu I, Soare T, Uzun S, Cojocaru VD, Pandele AM, Croitoru SM, Miculescu F, Cotrut CM, Dan I, Cimpean A. Characterization and In vitro and In vivo Assessment of a Novel Cellulose Acetate-coated Mg-based Alloy for Orthopaedic Applications, Materials, 2017, 10 (7), 686 (2017)

Voicu SI, Condruz RM, Mitran V, Cimpean A, Miculescu F, Andronescu C, Miculescu M, Thakur VK. Sericin Covalent Immobilization onto Cellulose Acetate Membrane for Potential Osseointegration Applications. ACS Sustainable Chem Eng, 4, 1765-1774 (2016).

Ion R, Luculescu C, Cimpean A, Marx P, Gordin D-M, Gloriant T. Nitride coating enhances endothelialization on biomedical NiTi shape memory alloy. Mater Sci Eng C, 62, 686–691 (2016).

Castany P, Gordin D-M, Drob SI, Vasilescu C, Mitran V, Cimpean A, Gloriant T. Deformation mechanisms and biocompatibility of the superelastic Ti–23Nb–0.7Ta–2Zr–0.5N alloy. Shap Mem Superelasticity, 2, 18-28 (2016).

Rusen L, Neacsu P, Cimpean A, Ion V, Brajnicova S, Dumitrescu LN, Banita J, Dinca V, Dinescu M. In vitro evaluation of poly(ethyleneglycol)-block-poly(e-caprolactone) methyl ether copolymer coating effects on cells adhesion and proliferation. Appl Surf Sci, 374, 23-30 (2016).

Ion R, Stoian AB, Dumitriu C, Grigorescu S, Mazare A, Cimpean A, Demetrescu I, Schmuki P. Nanochannels formed on TiZr alloy improve biological response. Acta Biomater, 24, 270-377 (2015).

Neacsu P, Mazare A, Schmuki P, Cimpean A. Attenuation of the macrophage inflammatory activity by TiOnanotubes via inhibition of MAPK and NF-kB pathways. Int J Nanomedicine, 10, 6455-6476 (2015).

Mitran V, Vasilescu C, Drob SI, Osiceanu P, Calderon Moreno JM, Tabirca MC, Gordin DM, Gloriant T, Cimpean A. Biological behaviour and enhanced anticorrosive performance of the nitrided superelastic Ti-23Nb-0.7Ta-2Zr-0.5N alloy. BioMed Res Int, 125, article ID  261802 (2015).

Drob SI, Vasilescu C, Calderon Moreno JM, Osiceanu P, Neacsu P, Cimpean A, Gordin DM, Gloriant T. Multifunctional "gum metal" titanium-based alloy: Its long-term electrochemical behaviour and macrophage response. Int J Electrochem Sci, 10, 10738-10755 (2015).

Mitran V, Albu MG, Vasile E, Cimpean A, Costache M. Dose-related effects of sericin on preadipocyte behavior within collagen/sericin hybrid scaffolds. Prog Nat Sci Mater Internat, 25, 122-130 (2015). (free access) 

Neacsu P, Ion RN, Mitran V, Staras AI, Cimpean A. State of the art and recent patents on Mg-based biodegradable bone implants. Rec. Pat. Regen. Med., Vol. 4, Nr. 3, 168-188 (2015). DOI: 10.2174/2210296505666150205155811

Ion R, Vizireanu S, Stancu CE, Luculescu C, Cimpean A, Dinescu Gh. Surface plasma functionalization influences macrophage behavior on carbon nanowalls, Mater Sci Eng C Mater Biol Appl, 48, 118-125 (2015).

Neacsu P, Gordin DM, Mitran V, Gloriant T, Costache M, Cimpean A. In vitro performance assessment of new beta Ti-Mo-Nb alloy compositions, Mater Sci Eng C Mater Biol Applic, 47, 105-113 (2015).

Neacsu P, Mazare A, Cimpean A, Park J, Costache M, Schmuki P, Demetrescu I. Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface, Int J Biochem Cell Biol, 55, 187-195 (2014).

Cimpean A, Vasilescu E, Drob P, Cinca I, Vasilescu C, Anastasescu M, Mitran V, Drob SI. Enhancement of the electrochemical behaviour and biological performance of Ti–25Ta–5Zr alloy by thermo-mechanical processing, Mater Sci Eng C Mater Biol Applic, 38, 127-142 (2014).

Cimpean A, Recent advances and challenges in adipose tissue engineering: Adipose derived stem cell-based approaches, Curr Tiss Eng, 3, 7-24 (2014).

Ion R, Gordin DM, Mitran V, Osiceanu P, Dinescu S, Gloriant T, Cimpean A, In vitro biocompatibility performances of the novel superelastic beta-type Ti-23Nb-0.7Ta-2Zr-0.5N alloy, Mater Sci Eng C Mater Biol Applic, 35, 411-419 (2014).

Ion R, Vasilescu C, Drob P, Vasilescu E, Cimpean A, Drob I, Gordin DM, Gloriant T. Long-term corrosion performances and cytocompatibility of nitrided Ti and Ti–6Al–4V alloy in severe functional conditions, Mater Corros, 65, 593-604 (2014).

Mindroiu M, Ion R, Pirvu C, Cimpean A, Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy, Mater Sci Eng C Mater Biol Applic, 33, 3353-3361 (2013).

Andronescu E, Ficai A, Albu M, Mitran V, Sonmez M, Ficai D, Ion R, Cimpean A. Collagen-hydroxyapatite/Cisplatin Drug Delivery Systems for Locoregional Treatment of Bone Cancer, Technol Cancer Res Treat, 12, 275-284 (2013).

Gordin DM, Gloriant T, Chane-Pane V, Busardo D, Mitran V, Hoche D, Vasilescu C, Drob SI, Cimpean A. Surface characterization and biocompatibility of titanium alloys implanted with nitrogen by Hardion+ technology, J Mater Sci: Mater Med, 23, 2953-2966 (2012).

Cimpean A, Mitran V, Ciofrangeanu CM, Galateanu B, Bertrand E, Gordin D-M, Iordachescu D, Gloriant T. Osteoblast cell behavior on the new beta-type Ti–25Ta–25Nb alloy, Mater Sci Eng C Mater Biol Applic, 32, 1554–1563 (2012).

Galateanu B., Dimonie D., Vasile E., Nae S., Cimpean A., Costache M., Layer-shaped Alginate Hydrogels Enhance the Biological Performance of Human Adipose-Derived Stem Cells, BMC Biotechnol 12, 35, (2012).

Galateanu B., Dinescu S., Cimpean A, Dinischiotu A, Costache M., Modulation of adipogenic conditions for prospective use of hADSCs in adipose tissue engineering, Int J Mol Sci, 13, 15881-15900, doi:10.3390/ijms130x000x (2012).

Dinescu S., Galateanu B., Albu M., Cimpean A., Dinischiotu A., Costache M., Sericin Enhances the Bioperformance of Collagen-Based Matrices Preseeded with Human-Adipose Derived Stem Cells (hADSCs), Int J Mol Sci, 14, 1870-1889; doi:10.3390/ijms14011870 (2013).

Vasilescu C, Calderon Moreno JM, Cimpean A, Cojocaru D, Cinca I, Andronescu E, Grigore F, Galateanu B, Drob SI, Synthesis, mechanical and structural properties and biological activity of some nanostructured bone scaffolds, Digest J Nanomat Biostr, 6, 523-534 (2011).

Cimpean A, Popescu S, Ciofrangeanu CM, Gleizes AN. Effects of LP-MOCVD prepared TiO2 thin films on the in vitro behavior of gingival fibroblasts, Mat Chem Phys, 125, 485-492 (2011).

Raducanu D, Cimpean A, Vasilescu E, Cojocaru VD, Cinca I, Drob P, Ivanescu S. Corrosion behaviour and biocompatibility of a new dental noble AuPdAgTi alloy, Mater Corros, 61, 775-782 (2010).

Scorei RI, Ciofrangeanu C, Ion R, Cimpean A, Galateanu B, Mitran V, Iordachescu D. In Vitro Effects of Calcium Fructoborate upon Production of Inflammatory Mediators by LPS-stimulated RAW 264.7 Macrophages, Biol Trace Elem Res,135, 334-344 (2010).
Scorei R, Ciubar R, Ciofrangeanu CM, Mitran V, Cimpean A, Iordachescu D. Comparative effects of boric acid and calcium fructoborate on breast cancer cells, Biol Trace Elem Res, 122, 197-205 (2008).

Popa MV, Demetrescu I, Iordachescu D, Cimpean A, Vasilescu E, Drob P, Vasilescu C, Istratescu M, The relation between electrochemical tests and in vitro evaluation of titanium alloy biocompatibility, Mater Corros, 58, 667-675 (2007).

Ciubar R, Ciofrangeanu C, Mitran V, Cimpean A, Stanescu A, Iordachescu D, The effect of lead ions on human erythrocytes in vitro, Rev Chim - Bucharest, 9, 895-808 (2007).

Scorei R, Ciubar R, Iancu C, Mitran V, Cimpean A, Iordachescu D, In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophils granulocytes, Biol Trace Elem Res, 118, 27-37 (2007).

Ciubar R, Mitran V, Cimpean A, Iordachescu D, In vitro effects of nickel on human embrionary lung fibroblasts, Rev Roum Chim, 51, 199-203, 2006.

Cimpean A, Stefan C, Gijsbers R, Stalmans W, Bollen M, Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2, Biochem J, 381, 71-77 (2004).






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Curriculum Vitae

File type .pdf ! CV Cimpean Anisoara

Online Resources


Last updated at: September 29, 2017.